I found these tips over at the Lord of the Rings online official forum.  You can find the full thread here .  Some of these are great:  there were quite a few that I didn't know!

User Interface

1. Control+Backslash: Brings up the UI, allowing you to customize it to your liking. ~from Diggl
2. You can drag items from your character sheet to your hot bars, items from your inventory to your hot bar to use.
3. Not only can you use Custom UI's, but you can make the other quick bars on your screen permanently visable, but you can use a compressed UI and move the Quick bars down to make it seem like a second row of quick slots without taking up any additional space on the screen. An example from Kaylan's great UI: http://www.lotrointerface.com/downloads/full30.jpg ~From Ascadia
4. 4. Use the map filters if you're looking for a specific NPC in towns. The option is located in the top left corner of the map (default M) ~From Hargreaves
5. 5. Right clickin on the General tab in the chat window allows you to turn off any of the player/system channels. It also allows you to color code the text for each of those channels!
6. Press the N key to toggle floating names on or off on the screen. This effects player names, NPC names, Creature Names, etc... ~From Aellea
7. 7. Under the UI section of the options, you can turn off the Ring Quest icon above quest NPCs. You can also turn off the Non-quest icons, like those for vendors, etc... ~From Aellea
8. Press the F12 key to toggle the entire UI on or off! ~From Aellea
9. Press Print Screen to take a screen shot. ~From Aellea
   

Look and Feel

1. Control+Left Click: On Armor or Weapons, it will allow you to see what that item will look like on your character. This works on NPC vendors, and even on quest rewards! ~From Synchro
2. Under advanced Video Setting, you can turn off helm, cape, shoe and other parts of your armor! ~From Dromiz  Note: All players will see the changes, so hobbits; show those feet!
3. In character generation, after picking race and gender; pick your region next! The color palettes for hair color, eye color, and skin color depend on region. For example, Men from Gondor may have darker skin tones than those from Bree-land, and while elves from Rivendell don't have a choice for grey hair... those from Lorien do. ~From Khafar
4. Pressing F12 to remove UI and then Ctrl + \ to unlock UI allows you to use mouselook to rotate your character in place! Find your favorite pose or look and then press Prt Src for a screenshot! ~Data_Ferret
• Holding down the left mouse button and the directional keys will also allow you to rotate your character in place. Handy for the uses Data_Ferret mentioned, and also for a quick behind you if you're getting chased by a big ole' nasty!
5. You can turn up animation detail under the advanced video options! (This helps smooth out animations at a greater distance, at the expense of performance) ~From Joslo
   

Npc Interaction

1. When selling, the amount at the bottom of the merchant window tells you the value of all items in your inventory if sold, except items "locked" by you! (Thanks for the clarification rocco81b!)
2. You don't need to be at a vendor to lock items. Remap your keys to assign a short cut to the function. Select an item and then use the shortcut to toggle the lock. ~From Makkilmakkil
3. Use F10, Shift+F10 and CTRL+F10 to allow you to select/cycle NPCs (remember to use the U key!) ~From Cozyflyer
4. Remember that trainers also have passive skills in which to train you; be sure to check them too. ~From Kulamata

Crafting and Harvesting:

1. Pressing DELETE will select the nearest node/item, after you approach it click U to automatically harvest nodes (useful for strawberries, yarrow and other hard to click ground spawns). ~From Cozyflyer
2. You do not need to be near a workbench in order to craft lore! Unlike the other crafting professions, you can camp Scholar node locations and grind out your crafting xp right there. ~From quigonwindu
3. When you dye something, you must unequip and re-equip the item to see the changes. ~From Sssnapdragon
4. Using /follow on a selected node will cause you to auto approach it. You can slot this using /shortcut.. ~From Istuilhos
5. 5. Read the description on purple items; usables ones will say they can be used in crafting - others you can still sell to npc vendors. ~From Arcaines
6. You can adjust the amount of the selected end product when crafting, by clicking in the window where you see the default "1". No more clicking the right arrow button 80 times for 80 items. ~From Delt

Combat

1. If you use the hotkey for a combat skill while you don't have a target, the closest target will be selected. ~From Makkilmakkil
2. 2. "Enable Skill Targetting Forwarding" allows you to execute your skills through that player to the monster. Conversely, if you have the monster selected, your friendly skills will execute through the monster to your fellow! ~From Shiara, Corpsearella
3. Under Combat Options, you can "Enable Combat Particle Response Indicators". For classes that rely on certain conditions for skills to be used this will show an effect around your character when the conditions are met, and allow you to react to it. Rather than looking at your hotbar at all the time ~From Thornfinger
4. If you attack a tagged mob, you will take a percentage of that person's xp. ~From acuoio
5. Under combat options turn on the "Directional Selection Indicator" in order to have a small line drawn from your character's feet to whatever you have selected!
6. Note: The line is color coded to indicate different types of objects. This is extremely useful for finding chests/scholar nodes ~From Suikoden4
7. Fellowship Manuevers (spheres) are bindable to hotkeys inside the keymapping options. Its near the very bottom of the list. Having to not click the sphere can save your life. ~From Flay
8. If you run low on morale and need to regen fast before your next battle, eating food helps. ~From Mirrordude
9. Spells, such as heals, will land on whomever was targeted when the spell was initiated, not on whom you are targeting when it actually finishes casting and lands. Thus, you can use the Assist function (mapped to "F" by default) to quickly switch from doing DPS or debuffing of a mob to healing the mob's target then back to attacking the mob in just three keystrokes ~From Voxin
   

Looting

1. When under Round Robin loot rules; chests and crates fall under this rule too! Make sure everyone loots the chest, they're not empty or being stingy with just copper! ~From Diggl
2. Shift+Right Clicking on a corpse will auto loot all items on the corpse, without a pop up window. (If partied, and set to uncommon; roll window still applies)
3. Shift+Right Clicking on a node will auto look a resource node without a pop up window! ~From B_Radr
• Alternatively, you can right click any corpse/node without using the default "U" key. (You'll still receive a loot window using this method.) ~From Slave_to_the_wheek

General Gameplay

1. Holding down the right mouse button while moving left or right allows you to stafe. (Aside from the default Q&E) ~From Diggl
2. Typing /rp on or /rp off will flag your character as Roleplaying or Not. ~From Corpsearella, CrazyJaxom
3. Alt+F10 illuminates the area around your character (Self only, others don't see it)
4. You can unlock special titlea by using emotes! Reference http://lotro-wiki.com/index.php/Titles ~From Missy
5. If you get with a meter or so of a chair in your local inn and type /sit you will sit down into the adjacent seat! ~From Soluna
6. Shift + Left Click a stack of items, then drag to another inventory slot and release. A stack splitting box will pop up where you can input the amount of items you want to put in the new inventory slot. ~From Corpsearella
7. Traits from Deeds stack. So if you want to get to Rank 4, you need to complete the deeds from several areas. Deeds automatically upgrade. No need to see a Bard if you've changed rank. ~From acuoio
8. Holding down the right and left mouse buttons together will allow you to move, turn and look with only your mouse hand rather than using the keyboard and mouse together. ~From Routman
9. Clicking on the ring on your quest log display in your interface will take you to that mission in your quest log. ~From Thorwen
10. Left clicking on the ring the quest tracker takes you to the entry in the quest log, but right clicking on it brings up a very useful context menu so you can remove the quest from the panel (or remove all), or set your LFF comment. It's very useful! ~From Zodiac
11. There is a color scheme to let you know the level of mobs that corresponds to your level. White quests and mobs are of equal level. Example: If the monster name appears in red and you are fighting him alone chances are you wont be winning that one. Elites tend to be stronger, making their level not as relevant as their HP, damage output and attack skills. ~From Emz66us68
    

Dying

1. Before level 10, your will not have item wear when you die.
2. Dying damages all your equipable items in your inventory, as well as the items you have equipped! ~From Synchro
3. You can die from falling, if the fall is from a great height. ~From Rocco81b
4. If you die from falling, your gear does not take any damage. ~From Diggl
   

Others:

1. Repair before leaving town, you never know how long you'll be out. ~From Rocco81b
• Alternatively, if you'll soon be outleveling or determine your repair costs will exceed your profits at your; repair selectively or wait until you have level/get your new gear to save costs! ~From Forohir and Steale
2. /loc Gives extensive coordinates (For use in bug reporting, etc). ;loc provides standard coordinates! ~From Rocco81b
3. To avoid spamming /say or any other channel, you can send a tell to yourself for coordinates! Type /tell <yourname>; loc ~From Shiara
4. If you want to see the progress on a deed you doing, hover your mouse over the deed progress bar and it will tell you exactly what you need and what you already have. ~From Arbit
5. Gold farmers use /who to spam their victims. To stop them, open the social panel (CTRL+O) and click the "Annonymous" check box. Voila! No more gold spam. ~From Rook818
6. Always look for a new stablemaster in a new town. Nothing is worse than visiting a new place and forgetting to grab the stablepoint, then realizing you missed it later. ~From Hargreaves
7. There's a great alias how-to thread over at Warcry that's worth a look for those new to them: http://lotro.warcry.com/content/guides/alias_macros ~From Soluna
8. Grab all the quests in an area before heading out. sometimes youll have to kill mob b to get to mob a. or youll have 2 quests that involve the same mob. so you can get 2 things done at once. ~From nevikt
9. Destiny points are shared between all charcaters on one server! ~From pvthudson01
10. The suppliers sell Bronze versions of all the crafting tools. These are far more durable than the tools you start out with, and do not have any duration or crit-penalties. ~From Forohir
11. You can carry multiple harvesting tools - this will allow you to harvest longer without needing to repair. ~From Thehiredgun
12. If you don't see many creatures of a specific type in an area you know they should be in, kill everything else so more stuff will respawn. Oh, and pick all the plants too! (Explanation: Plants are in the same spawn table as creatures, so that Raspberry bush may respawn as a warg if you pluck it! Also, if wargs are 25% of the spawns and are "cherry-picked" out of the landscape, in the next round of spawns they'll only be about 6% - 25% of 25%. So kill everything to get more of what you want). ~From Khafar
13. Temporary Experience Bonus (Destiny Points): A lot of folks seem to assume the XP bonus bought with DP is just a +X% for Y time duration based on the "temporary" description. However, in reality it's not a buff or any real sort of temporary duration. What it does is literally buy you "Rested XP". At around Lv15, for just 150 DP (or was it 250 DP), you can buy Rested XP for about 25% of the entire level. As far as I can tell, it lasts forever just like naturally accumulated Rested XP! ~From KyanMehWulfe
14. Save your Sweet Lobelia seeds. Each character can only do the quest once that gives you your few precious seeds--they can't be bought, except maybe at the AH. If you try to crossbreed them (at least until seed yields are fixed), you will lose them all before you can make Eagle's Nest. ~From Calimmacil
15. Not all agro mobs will attack right away. If you get them past them quickly they will just ignore you. Example: Cave claws. You will see message saying they are threatening to attack, but you can run through whole groups of them and they will not chase you. If you stand still though they will indeed come after you. ~ScottAdams
16. If your character name has been changed to *renameme* etc by Turbine, you don't to contact a GM. Just type /rename to rename your character. ~From Rocco81b